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Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder
Author(s) -
Lee HeonJeong,
Lee MinSoo,
Kang RheeHun,
Kim Hyun,
Kim SoonDuck,
Kee BaikSeok,
Kim Young Hoon,
Kim YongKu,
Kim Jung Bum,
Yeon Byung Kil,
Oh Kang Seob,
Oh ByungHoon,
Yoon JinSang,
Lee Chul,
Jung Han Yong,
Chee IkSeung,
Paik In Ho
Publication year - 2005
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.20064
Subject(s) - serotonin transporter , serotonergic , anxiety , genotype , anxiety disorder , psychology , 5 httlpr , etiology , depression (economics) , posttraumatic stress , genetic predisposition , polymorphism (computer science) , clinical psychology , allele , allele frequency , psychiatry , medicine , serotonin , genetics , gene , biology , receptor , disease , macroeconomics , economics
Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin‐transporter‐linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case–control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment. Depression and Anxiety 00:1–5, 2005 . © 2005 Wiley‐Liss, Inc.