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Clinical correlates of recurrent major depression in obsessive–compulsive disorder
Author(s) -
Hong Jin Pyo,
Samuels Jack,
Bienvenu O. Joseph,
Cannistraro Paul,
Grados Marco,
Riddle Mark A.,
Liang KungYee,
Cullen Bernadette,
HoehnSaric Rudolf,
Nestadt Gerald
Publication year - 2004
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.20024
Subject(s) - anxiety , schedule for affective disorders and schizophrenia , psychiatry , depression (economics) , anxiety disorder , psychology , clinical psychology , comorbidity , proband , family history , generalized anxiety disorder , schizophrenia (object oriented programming) , logistic regression , age of onset , major depressive disorder , medicine , disease , mood , biochemistry , chemistry , gene , economics , mutation , macroeconomics
Abstract Major depressive disorder is the most frequent comorbid condition in obsessive–compulsive disorder (OCD). This study investigated factors associated with the development of recurrent major depressive disorder (RDD) in patients with OCD. Eighty OCD cases and 73 control probands were examined by psychiatrists or clinical psychologists using the Schedule for Affective Disorders and Schizophrenia–Lifetime Anxiety (SADS‐LA). Two experienced psychiatrists independently reviewed all clinical materials and made final consensus diagnoses using DSM‐IV criteria. Family history of OCD and RDD, additional comorbid disorders, OCD symptoms and illness severity were compared between persons with OCD alone ( n =21) and OCD with RDD ( n =41). Compared to OCD probands without RDD, OCD probands with RDD had earlier age at first diagnosis, more severe obsessive–compulsive symptoms, and were more likely to have a family history of RDD. Social phobia, separation anxiety disorder, and body dysmorphic disorder occurred more frequently in the comorbid group. In a multiple logistic regression model, only early age of OCD diagnosis was significantly associated with RDD. Early age at onset of OCD increases the risk of depressive disorder in individuals with OCD. Depression and Anxiety 00:000–000, 2004. © 2004 Wiley‐Liss, Inc.