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Increased premenstrual dosing of nefazodone relieves premenstrual magnification of depression
Author(s) -
Miller Merry N.,
Miller Barney E.,
Chinouth Rick,
Coyle Brent R.,
Brown George R.
Publication year - 2002
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.1086
Subject(s) - nefazodone , placebo , dosing , luteal phase , depression (economics) , premenstrual dysphoric disorder , crossover study , psychology , medicine , menstrual cycle , anesthesia , follicular phase , hormone , fluoxetine , receptor , alternative medicine , pathology , serotonin , economics , macroeconomics
We report on 3 subjects with premenstrual magnification of major depression (PMMD) treated with nefazodone who benefited from a supplement of additional nefazodone premenstrually. During the 6‐month study, subjects were given supplements of either additional nefazodone or placebo prior to the expected onset of menses (double‐blind crossover design). Symptoms were assessed during the late luteal and follicular phases. All subjects showed significant improvement for the months in which they received nefazodone supplements, but not when given placebo. Premenstrual dose increase is a clinically promising intervention for women who experience PMMD. Depression and Anxiety 15:48–51, 2002. © 2002 Wiley‐Liss, Inc.