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Brain metabolic changes during lactate‐induced panic: Effects of gabapentin treatment
Author(s) -
Layton Matthew E.,
Friedman Seth D.,
Dager Stephen R.
Publication year - 2001
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.1076
Subject(s) - sodium lactate , gabapentin , panic disorder , placebo , anesthesia , medicine , panic , magnetic resonance imaging , sodium , chemistry , pathology , radiology , psychiatry , anxiety , alternative medicine , organic chemistry
Abstract Six subjects with panic disorder underwent sodium lactate infusions in conjunction with magnetic resonance spectroscopic imaging (MRSI) at study entrance when actively symptomatic and after clinical improvement while under treatment with gabapentin. MRSI was used to serially measure regional brain lactate levels from an axial section at the level of the lateral ventricles at baseline, during lactate infusion and postlactate infusion. Gabapentin treatment appeared to be effective in blocking a lactate‐induced panic response but did not alter the magnitude or time course of an abnormal brain lactate response to lactate infusion in all subjects. Additionally, two subjects were reinfused while clinically improved on double‐blind placebo and demonstrated a consistent pattern of abnormal brain lactate response. Depression and Anxiety 14:251–254, 2001. © 2001 Wiley‐Liss, Inc.