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Potential mechanisms of the sleep therapies for depression
Author(s) -
Ringel Brenda L.,
Szuba Martin P.
Publication year - 2001
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.1044
Subject(s) - antidepressant , depression (economics) , sleep deprivation , psychiatry , intervention (counseling) , psychology , major depressive disorder , bipolar disorder , medicine , treatment resistant depression , lithium (medication) , mood , anxiety , cognition , economics , macroeconomics
Sleep deprivation for one night has been investigated as a treatment for depression since the first publications describing its antidepressant properties almost 30 years ago [Pflug and Tolle, 1971: Int Pharmacopsychiatry 6:187–196]. It remains a field of active research. It is the only intervention consistently demonstrated to produce next‐day antidepressant results. This makes sleep deprivation an exciting and unique tool to study the pathophysiology of depressive disorders and to formulate targets for novel antidepressant agents. Importantly, it is also an effective, but underused, clinical treatment for unipolar and bipolar depression. Depression and Anxiety 14:29–36, 2001. © 2001 Wiley‐Liss, Inc.