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Chronic inositol treatment reduces depression‐like immobility of Flinders Sensitive Line rats in the forced swim test
Author(s) -
Einat Haim,
Belmaker Robert H.,
Zangen Avraham,
Overstreet D.H.,
Yadid Gal
Publication year - 2002
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.10025
Subject(s) - behavioural despair test , depression (economics) , inositol , psychology , psychiatry , clinical psychology , medicine , antidepressant , receptor , anxiety , economics , macroeconomics
Inositol, a precursor of the PIP cycle that was reported to have therapeutic effects in depressive patients and to be effective in two animal models of depression, was evaluated in the forced swim test using the genetic Flinders Sensitive Line (FSL) rats model of depression. Groups of rats were tested in a 2 × 2 design with Strain (FSL or Control) as one factor and Drug (Inositol or Placebo) as the second factor. Rats received chronic treatment (daily for 14 days) with inositol (1.2 g/kg) or placebo (1:2 glucose/mannitol solution). On day 14 rats were exposed to the forced swim test for 5 min and their behavior videotaped. Tapes were analyzed for three levels of activity: immobility, swimming, and vigorous struggle. Inositol countered the exaggerated immobility of FSL rats in the forced swim test, without affecting control animals. Data support our previous suggestion of inositol as a potential antidepressant. Depression and Anxiety 15:148–151, 2002. © 2002 Wiley‐Liss, Inc.