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Polyclonal B‐cell lymphocytosis: Report of three cases
Author(s) -
Marcondes Natália Aydos,
Schneider Laiana,
Spindler Bianca Michel,
Fernandes Flavo Beno,
Faulhaber Gustavo Adolpho Moreira
Publication year - 2018
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.21638
Subject(s) - lymphocytosis , immunophenotyping , medicine , flow cytometry , cd5 , pathology , polyclonal antibodies , monocytosis , immunology , antibody , bone marrow
Background Persistent polyclonal B‐cell lymphocytosis (PPBL) is a rare benign condition characterized by a polyclonal B‐cell lymphocytosis with binucleated lymphocytes. We hereby report three cases of PPBL. Methods Flow cytometry immunophenotyping was performed in peripheral blood samples from three patients with clinical suspicion of lymphoproliferative disease. Results Case 1 was a female middle‐aged smoker; Case 2 was an elderly male; and Case 3 was a non‐smoker female. Flow cytometry evaluation of all cases revealed an expansion of mature B‐cells, with a normal Kappa/Lambda light chain ratio; B‐cell lymphocytes of Cases 2 and 3 had CD5 coexpression; Case 3 also had monocytosis. Conclusions Diagnose of PPBL is important in order to avoid unnecessary diagnostic procedures and therapy. © 2018 International Clinical Cytometry Society