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CD 5 positive hairy cell leukemia: A rare case report with brief review of literature
Author(s) -
Jain Dharmendra,
Dorwal Pranav,
Gajendra Smeeta,
Pande Amit,
Mehra Simmi,
Sachdev Ritesh
Publication year - 2016
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.21365
Subject(s) - cd5 , interleukin 3 receptor , pdgfra , medicine , cd11c , hairy cell leukemia , flow cytometry , leukemia , cancer research , chemistry , immunology , gene , biochemistry , phenotype , gist , stromal cell
Objective The aberrant expression of CD5 in both HCL and HCL‐v is a very rare event. Although a number of CD5 positive HCL and HCL‐v cases have been reported, but these are far and few in between. We aimed to review the reported cases of CD5 positive HCL and its variant. Method We hereby report a case of CD5 positive HCL, with variations in PIK3CA and PDGFRA gene, along with a brief review of literature of the cases of CD5 positive HCL and its variant. Results and Conclusion The current case was positive for CD103, CD11c, CD25, and CD123 which has led the diagnosis to be of typical HCL. With the extensive literature review we found that only 26 cases of hairy cell leukemia [HCL and HCL‐v] bearing CD5 expression have been reported so far. The positivity of CD5 is more common in HCL‐v as compared to HCL. Additional prospective studies of CD5+ HCL and its variants are required to show whether they are a clinically significant subgroup of lymphoid malignancies. © 2016 International Clinical Cytometry Society