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Mixed phenotypic acute leukemia with two immunophenotypically distinct blast populations: Report of an unusual case
Author(s) -
Rahman Khaliqur,
George Seena,
Tewari Apoorvi,
Mehta Anurag
Publication year - 2013
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.21086
Subject(s) - immunophenotyping , pallor , bone marrow , myeloid leukemia , leukemia , flow cytometry , phenotype , pathology , myeloid , acute leukemia , medicine , immunology , biology , genetics , gene
Mixed phenotypic acute leukemia (MPAL) is a rare disorder with an incidence of less than 2% of all acute leukemia using the recent 2008 WHO criteria. Common subtypes encountered are the B/myeloid and T/myeloid; B/T or trilineage MPAL being an exception. We discuss here a case of 20‐year‐male patient who presented with pallor and generalised lymphadenopathy. Peripheral blood smear examination showed presence of 61% blasts of lymphoid morphology. Immunophenotyping by multicolor flow cytometry showed two distinct populations of blasts with T and B phenotype respectively. He was diagnosed as MPAL with two distinct blast lineages. Conventional karyotyping done on bone marrow sample showed t(9;22)(q34;q11)(Ph +). Induction was started using ALL based protocol. The patient is on follow up with post induction marrow being in morphological remission. © 2013 International Clinical Cytometry Society