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The hematopoietic stem cell niche—home for friend and foe?
Author(s) -
Krause Daniela S.,
Scadden David T.,
Preffer Frederic I.
Publication year - 2012
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.21066
Subject(s) - niche , haematopoiesis , stem cell , hematopoietic stem cell , biology , stem cell niche , immunology , microbiology and biotechnology , progenitor cell , ecology
The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self‐renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche. © 2012 International Clinical Cytometry Society