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Peripheral blood flow cytometry based diagnosis in primary cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma: Implications for more extensive use
Author(s) -
Benetatos Leonidas,
Dova Lefkothea,
Baxevanos Gerasimos,
Kolaitis Nikolaos I.,
Bourantas Konstantinos L.,
Vartholomatos Georgios
Publication year - 2009
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.20447
Subject(s) - flow cytometry , cd8 , medicine , lymphoma , peripheral blood mononuclear cell , pathology , monoclonal antibody , antigen , antibody , cytometry , immunology , biology , biochemistry , in vitro
Primary cutaneous epidermotropic CD8‐positive T‐cell lymphoma represents an aggressive form of T‐cell cutaneous lymphomas. Diagnosis is based on biopsies obtained from skin lesions. Here, we would like to report a case diagnosed by using flow cytometry performed on peripheral blood mononuclear cells. Moreover, an important finding was the difference in the results on targeting the CD8 antigen by using two different commercially available monoclonal antibodies. Perhaps, more than one antibody should be used in primary cutaneous aggressive epidermotropic CD8‐positive T‐cell lymphomas, in orderto be more accurate in the diagnosis and so in the classification of such diseases. © 2008 Clinical Cytometry Society