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Improved detection of minimal acute myeloid leukemia cells by the use of the combined parameters of XE‐2100 hematology analyzer
Author(s) -
Tohyama Kaoru,
Shiga Shuichi,
Itose Yuji,
Uchihashi Kinya,
Ohkura Mitsugi,
Takahashi Keiko,
Itoh Mitsuru,
Ichiyama Satoshi,
Hamaguchi Yukio
Publication year - 2005
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.20053
Subject(s) - hematology analyzer , myeloid leukemia , hematology , medicine , flag (linear algebra) , sensitivity (control systems) , leukemia , acute leukemia , precursor cell , myeloid , oncology , biology , mathematics , cell , genetics , electronic engineering , pure mathematics , engineering , algebra over a field
Abstract Background For the diagnosis and therapy of acute leukemia, it is important to detect a small number of leukemic cells precisely. Although several automated hematology analyzers that carry blast‐detecting programs have been developed, they do not exert sufficient detection sensitivity to exceed the sensitivity of manual eye counting method. Methods We constructed a new blast‐detecting program by combining the numerical information acquired from five cytometric parameters presented by XE‐2100. The sensitivity and specificity of this blast multi‐scoring program were assessed in comparison with the Blasts flag program equipped originally in XE‐2100. Results The blast‐detecting sensitivity was found to be highly improved in the blast multi‐scoring program as compared with the Blasts flag program without much decreasing the specificity. A small number of leukemic myeloblasts was detected at the better sensitivity than the eye counting method in the clinical course of the patients with acute myeloid leukemia. Conclusions The daily practical use of this blast multi‐scoring program will surely contribute to sensitive, objective, and real‐time evaluation of the control of acute myeloid leukemia with a low cost. © 2005 Wiley‐Liss, Inc.