Premium
Role of pro‐atherogenic adhesion molecules and inflammatory cytokines in patients with coronary artery disease and diabetes mellitus type 2
Author(s) -
Peschel Thomas,
Niebauer Josef
Publication year - 2003
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.10026
Subject(s) - medicine , diabetes mellitus , cell adhesion molecule , disease , coronary artery disease , pathophysiology , type 2 diabetes mellitus , inflammation , bioinformatics , cardiology , immunology , endocrinology , biology
Accelerated progression of atherosclerosis in coronary, carotid, cerebral, and peripheral arteries is a phenomenon observed in diabetes mellitus. Pathophysiologic mechanisms are slowly being understood. Pro‐atherogenic adhesion molecules and inflammatory cytokines are involved in this process. This review addresses current concepts of atherogenesis and focuses on alterations of adhesion molecule and cytokine expression and their regulation in diabetic patients. Molecules are being discussed in both the normoglycemic and hyperglycemic states, with a focus on their atherogenic role in diabetes mellitus. Understanding the mechanisms that underlie disease progression will help to identify high‐risk patients, which is a prerequisite for new treatment strategies aiming at an attenuation of disease progression in diabetic patients. Cytometry Part B (Clin. Cytometry) 53B:78–85, 2003. © 2003 Wiley‐Liss, Inc.