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Guess what: Chronic 13q14.3 + /CD5 − /CD23 + lymphocytic leukemia in blood and t(11;14)(q13;q32) + /CD5 + /CD23 − mantle cell lymphoma in lymph nodes!
Author(s) -
Lima Margarida,
Pinto Luísa,
Dos Anjos Teixeira Maria,
Canelhas Áurea,
Mota Alexandra,
Cabeda José Manuel,
Silva Cidália,
Queirós Maria Luís,
Fonseca Sónia,
Santos Ana Helena,
Brochado Paulo,
Justiça Benvindo
Publication year - 2003
Publication title -
cytometry part b: clinical cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 61
eISSN - 1552-4957
pISSN - 1552-4949
DOI - 10.1002/cyto.b.10005
Subject(s) - cd5 , chronic lymphocytic leukemia , mantle cell lymphoma , clone (java method) , cd23 , microbiology and biotechnology , lymphoproliferative disorders , leukemia , pathology , flow cytometry , biology , medicine , chemistry , immunology , antibody , lymphoma , immunoglobulin e , genetics , dna
Abstract We report a case of a patient with two B‐cell lymphoproliferative disorders: CD5 − /CD23 + B‐cell chronic lymphocytic leukemia and CD5 + /CD23 − mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction–based molecular studies. The B‐cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes. Cytometry Part B (Clin. Cytometry) 51B:41–44, 2003. © 2002 Wiley‐Liss, Inc.