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Comprehensive Phenotyping of Human Dendritic Cells and Monocytes
Author(s) -
Mair Florian,
Liechti Thomas
Publication year - 2021
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.24269
Subject(s) - phenotype , dendritic cell , biology , adaptation (eye) , cell type , functional diversity , immunology , monocyte , microbiology and biotechnology , antigen presenting cell , cell , computational biology , antigen , neuroscience , t cell , immune system , gene , genetics , ecology
Professional antigen‐presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T‐cell responses. Recent technological developments in single‐cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue‐specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine‐grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.