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Lymphocyte Subset Counts in COVID ‐19 Patients: A Meta‐Analysis
Author(s) -
Huang Wei,
Berube Julie,
McNamara Michelle,
Saksena Suraj,
Hartman Marsha,
Arshad Tariq,
Bornheimer Scott J.,
O'Gorman Maurice
Publication year - 2020
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.24172
Subject(s) - covid-19 , lymphocyte , lymphocyte subsets , immunology , virology , biology , computational biology , medicine , immune system , t cell , infectious disease (medical specialty) , outbreak , disease
A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID‐19) patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 20 peer‐reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID‐19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID‐19 disease compared to mild/moderate disease. T‐cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T‐cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry