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Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry
Author(s) -
Del Zotto Genny,
Antonini Francesca,
Pesce Silvia,
Moretta Francesca,
Moretta Lorenzo,
Marcenaro Emanuela
Publication year - 2020
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.24001
Subject(s) - flow cytometry , biology , immune system , microbiology and biotechnology , immunology , cell , autoimmunity , innate immune system , cytometry , receptor , compartment (ship) , phenotype , mass cytometry , biochemistry , genetics , oceanography , gene , geology
The NK cell compartment provides powerful innate defenses against virus‐infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different functional capabilities exist and this reflects not only the different maturation stages of NK cells but also different microenvironments in which they can operate. In this review, we will give an overview on the various NK cell subsets present in peripheral blood of healthy donors in order to clearly and univocally identify them on the basis of their phenotypic traits using flow cytometry. © 2020 International Society for Advancement of Cytometry