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Equine cellular therapy—from stall to bench to bedside?
Author(s) -
Burk Janina,
Badylak Stephen F.,
Kelly Jeremy,
Brehm Walter
Publication year - 2013
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.22216
Subject(s) - stem cell , medicine , mesenchymal stem cell , cell therapy , regenerative medicine , embryonic stem cell , bench to bedside , stem cell therapy , pathology , biology , microbiology and biotechnology , medical physics , biochemistry , gene
Pioneering clinical stem cell research is being performed in the horse, a recipient of cutting edge veterinary medicine as well as a unique animal model, paving the way for human medical applications. Although demonstrable progress has been made on the clinical front, in vitro characterization of equine stem cells is still in comparatively early stages. To translate the promising results of clinical stem cell therapy in the horse, advances must be made in the characterization of equine stem cells. Aiming to improve communication between veterinarians and other natural scientists, this review gives an overview of veterinary “bedside” achievements, focusing on stem cell therapies in equine orthopedics as well as the current state of in vitro characterization of equine multipotent mesenchymal stromal cells (MSCs) and equine embryonic stem cells (ESCs). © 2012 International Society for Advancement of Cytometry