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Isolation and differentiation properties of neural crest stem cells
Author(s) -
Dupin Elisabeth,
CoelhoAguiar Juliana M.
Publication year - 2013
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.22098
Subject(s) - neural crest , biology , stem cell , neural stem cell , microbiology and biotechnology , neural fold , progenitor cell , neurosphere , cell type , adult stem cell , anatomy , neural plate , endothelial stem cell , cell , in vitro , embryo , genetics
A wide array of neural and non‐neural cell types arises from the neural crest during vertebrate embryogenesis. The neural crest forms transiently in the dorsal neural primordium to yield migratory cells that will invade nearly all tissues and later, differentiate into bones and cartilages, vascular smooth muscle cells, connective tissues, neurons and glial cells of the peripheral nervous system, endocrine cells, and melanocytes. Due to the amazingly diversified array of cell types they generate, the neural crest cells represent an attractive model in the stem cell field. We review here in vivo and in vitro studies of individual cells, which led to the discovery and characterization of neural crest progenitors endowed with multipotency and stem cell properties. We also present an overview of the diverse types, marker expression, and locations of the neural crest‐derived stem cells identified in the vertebrate body, with emphasis on those evidenced recently in mammalian adult tissues. © 2012 International Society for Advancement of Cytometry