Fluorogen‐activating proteins as biosensors of cell‐surface proteins in living cells | Zendy

Holleran John | Zendy; Brown Dara | Zendy; Fuhrman Margaret H. | Zendy; Adler Sally A. | Zendy; Fisher Gregory W. | Zendy; Jarvik Jonathan W. | Zendy

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Fluorogen‐activating proteins as biosensors of cell‐surface proteins in living cells

Author(s) -

Holleran John,

Brown Dara,

Fuhrman Margaret H.,

Adler Sally A.,

Fisher Gregory W.,

Jarvik Jonathan W.

Publication year - 2010

Publication title -

cytometry part a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.316

H-Index - 90

eISSN - 1552-4930

pISSN - 1552-4922

DOI - 10.1002/cyto.a.20925

Subject(s) - biosensor , fluorescence , chemistry , cell , biophysics , molecule , nanotechnology , microbiology and biotechnology , biochemistry , biology , materials science , physics , organic chemistry , quantum mechanics

This study explores the general utility of a new class of biosensor that allows one to selectively visualize molecules of a chosen membrane protein that are at the cell surface. These biosensors make use of recently described bipartite fluoromodules comprised of a fluorogen‐activating protein (FAP) and a small molecule (fluorogen) whose fluorescence increases dramatically when noncovalently bound by the FAP (Szent‐Gyorgyi et al., Nat Biotechnol 2010;00:000–000). © 2010 International Society for Advancement of Cytometry

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