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Good cell, bad cell: Flow cytometry reveals T‐cell subsets important in HIV disease
Author(s) -
Chattopadhyay Pratip K.,
Roederer Mario
Publication year - 2010
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.20905
Subject(s) - flow cytometry , cell , cytometry , disease , human immunodeficiency virus (hiv) , biology , computational biology , microbiology and biotechnology , immunology , medicine , pathology , genetics
Flow cytometry is a key technology in the study of HIV disease. In this article, we review various cellular markers that can be measured in the setting of pathogenesis or vaccination studies, including markers of activation, differentiation, senescence, immune suppression, and function. In addition, we discuss important considerations for making these measurements. Finally, we examine how flow cytometry studies have taught researchers about the disease process, and the potential for flow cytometry technology to guide treatment decisions and evaluate vaccine candidates in the future. Published 2010 Wiley‐Liss, Inc.