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The central nervous system as target for antihypertensive actions of a proline‐rich peptide from Bothrops jararaca venom
Author(s) -
Lameu Claudiana,
Hayashi Mirian A. F.,
Guerreiro Juliano R.,
Oliveira Eduardo F.,
Lebrun Ivo,
Pontieri Vera,
Morais Kátia L. P.,
Camargo Antonio C. M.,
Ulrich Henning
Publication year - 2010
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.20860
Subject(s) - bradykinin , venom , pertussis toxin , peptide , bothrops jararaca , chemistry , calcium , calcium in biology , pharmacology , receptor , biochemistry , medicine , biology , snake venom , g protein
Pyroglutamyl proline‐rich oligopeptides, present in the venom of the pit viper Bothrops jararaca ( Bj ‐PROs), are the first described naturally occurring inhibitors of the angiotensin I‐converting enzyme (ACE). The inhibition of ACE by the decapeptide Bj ‐PRO‐10c (