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Volume 75A, Number 7, July 2009 Cover Image
Publication year - 2009
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.20761
Subject(s) - demethylation , methylation , homogeneous , dna methylation , microbiology and biotechnology , transcription (linguistics) , rendering (computer graphics) , biology , computer science , chemistry , computer graphics (images) , mathematics , dna , combinatorics , gene expression , biochemistry , gene , philosophy , linguistics
Sites of hypermethylation and demethylation of nuclear foci affected epigenetically by drugs or the environment show places of transcription modulation, i.e. activation or deactivation. In consequence, these changes may lead to differentiation or dedifferentiation of a cell. Gertych et al. quantitate in their sophisticated work these foci (dots within the triangles in the artist's rendering) and show that responses of seemingly similar cells (triangles) in a homogeneous cell culture are clearly varying in their number and extent of methylation sites. See the accompanying article on page 569 in this issue