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Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children
Author(s) -
Bocsi József,
Richter Margit,
Hambsch Jörg,
Barten Markus J.,
Dähnert Ingo,
Schneider Peter,
Tárnok Attila
Publication year - 2006
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.20213
Subject(s) - cardiopulmonary bypass , medicine , cardiac surgery , edema , anesthesia , inflammatory response , cardiology , inflammation
Background Cardiac surgery with cardiopulmonary bypass (CPB) induces substantial release of IL‐10, indicating increased Th2 cell response. Therefore, in this study, we wanted to verify if this response is due to CPB or surgical trauma, and to study its relation to postoperative effusions and edema (POEE) in children. Methods Th1/Th2 reaction was monitored in children undergoing cardiovascular surgery with ( n = 75) and without CPB ( n = 29). Results Surgery with CPB compared to surgery without CPB induced a transient shift towards Th2. Elevated Th2 response was related to increased vascular permeability and POEE. Conclusion The immune suppression/Th2 response is typical for CPB, and at intermediate level is tolerable but at high level could be adverse for the patients. © 2006 International Society for Analytical Cytology