Open AccessA unified model of eukaryotic chromosomes
Author(s) -
Manuelidis Laura,
Chen Terence L.
Publication year - 1990
Publication title -
cytometry
Language(s) - English
Resource type - Journals
eISSN - 1097-0320
pISSN - 0196-4763
DOI - 10.1002/cyto.990110104
Subject(s) - euchromatin , heterochromatin , eukaryotic chromosome fine structure , biology , metaphase , dna , genetics , dna replication , computational biology , repeated sequence , chromosome , chromatin , gene , genome , telomere
A revised model of DNA packaging into chromosomes is presented. Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains. Thetransitions between euchromatic, heterochromatic and metaphase states are explained simply. Molecular and physical properties of chromosomal bands, and their correlation with specific DNA sequence motifs are discussed.