Open AccessDetection of bladder carcinoma in females by flow cytometry and cytology
Author(s) -
Hermansen Dane K.,
Badalament Robert A.,
Fair William R.,
Kimmel Marek,
Whitmore Willet F.,
Melamed Myron R.
Publication year - 1989
Publication title -
cytometry
Language(s) - English
Resource type - Journals
eISSN - 1097-0320
pISSN - 0196-4763
DOI - 10.1002/cyto.990100611
Subject(s) - cystoscopy , cytology , urine cytology , urology , bladder cancer , urinary bladder , medicine , flow cytometry , pyuria , population , cancer , urinary system , carcinoma , cytometry , gynecology , pathology , immunology , environmental health
The sensitivity of bladder wash flow cytometry (BWFCM), voided urinary cytology (VUC), and cytology of cathetrized urine obtained at the time of cystoscopy (CUC) were reviewed on all women evaluated for bladder cancer at Memorial Sloan‐Kettering Cancer Center between June 1985 and December 1986. This comprised sixty‐four episodes of pathologically proven bladder cancer in 48 women. Considering positive and suspicious results jointly the sensitivities of BWFCM, CUC and 3 VUC were 75%, 64% and 56%, respectively. If only positive results were considered (i.e., suspicious results considered as negative), the sensitivities of BWFCM, CUC and 3 VUC were 64%, 31% and 32%, respectively. The sensitivities of these tests are less than for a predominantly male population, presumably related to the presence of squamous epithelium and greater frequency of pyuria. However, bladder wash flow cytometry and conventional cytology are still a very valuable addition to cystoscopic examination, and the combination of BWFCM with conventional cytology is more sensitive than either procedure alone.