Open AccessA new model for the quantitative analysis of cell movements in vitro: Definition of a shape change factor
Author(s) -
Verschueren Hendrik,
Van Larebeke Nicolas
Publication year - 1984
Publication title -
cytometry
Language(s) - English
Resource type - Journals
eISSN - 1097-0320
pISSN - 0196-4763
DOI - 10.1002/cyto.990050602
Subject(s) - motility , biological system , translation (biology) , shape change , interval (graph theory) , shape analysis (program analysis) , chromosomal translocation , quantitative analysis (chemistry) , measure (data warehouse) , microbiology and biotechnology , biology , computer science , biophysics , mathematics , chemistry , data mining , genetics , chromatography , combinatorics , messenger rna , gene , static analysis , ecology
Changes in shape, in addition to translocations, are an important aspect of cell motility. We propose a simple geometrical model for the quantitative analysis of shape changes undergone by cultured cells. The extent to which images of a given cell do not overlap at the beginning and end of a time interval is used as a measure of motility, and a translation step included to eliminate translocation effects. Initial findings suggest that the method is widely applicable.