Open AccessCorrelation between cytometric features and mitotic frequency in human breast carcinoma
Author(s) -
Stenkvist Björn,
Bengtsson Ewert,
Eriksson Olle,
Jarkrans Torsten,
Nordin Bo,
WestmanNaeser Sighild
Publication year - 1981
Publication title -
cytometry
Language(s) - English
Resource type - Journals
eISSN - 1097-0320
pISSN - 0196-4763
DOI - 10.1002/cyto.990010408
Subject(s) - mitosis , correlation , mitotic index , breast carcinoma , human breast , feature (linguistics) , biology , variance (accounting) , breast cancer , pathology , cancer , medicine , mathematics , microbiology and biotechnology , genetics , linguistics , geometry , philosophy , accounting , business
An evaluation of cytometric features of 142 human breast cancers was performed. Twenty‐two cytometric features describing density, structure and shape were correlated with mitotic frequency and labeling index of some of the tumors and with the observed recurrence rate of the tumors within 3 years after removal of the breast. A new cytometric measure was also created by combining the four features most strongly correlated with mitotic frequency of the tumors. It was found that the variance of the nuclear area was the feature that was most strongly correlated with mitotic frequency and recurrence rate. No new cytometric measure created by combining the four features most strongly correlated with mitotic frequency, correlated as well as variance of nuclear area even though the four features were optimized by multiple regression analysis for their correlation with mitotic frequency.