Whole‐genome methylome analysis reveals age‐related diabetes risk factors | Zendy

Hai Luo | Zendy; Liu Zongzhi | Zendy; Chen Wei | Zendy; Qiao Jie | Zendy; Sun Yingli | Zendy

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Whole‐genome methylome analysis reveals age‐related diabetes risk factors

Author(s) -

Hai Luo,

Liu Zongzhi,

Chen Wei,

Qiao Jie,

Sun Yingli

Publication year - 2020

Publication title -

clinical and translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 1

ISSN - 2001-1326

DOI - 10.1002/ctm2.93

Subject(s) - dna methylation , epigenetics , cpg site , single nucleotide polymorphism , genetics , kegg , diabetes mellitus , biology , expression quantitative trait loci , methylation , quantitative trait locus , insulin resistance , biomarker , bioinformatics , medicine , gene , endocrinology , genotype , transcriptome , gene expression

This study provides a new perspective on the relationship between age‐related DNA methylation and insulin function. The hexokinase‐1 ( HK1 )’s methylation level in the whole blood can be considered as a potential biomarker for the risk of diabetes in healthy individuals.

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