Open AccessWhole‐genome methylome analysis reveals age‐related diabetes risk factors
Author(s) -
Hai Luo,
Liu Zongzhi,
Chen Wei,
Qiao Jie,
Sun Yingli
Publication year - 2020
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.93
Subject(s) - dna methylation , epigenetics , cpg site , single nucleotide polymorphism , genetics , kegg , diabetes mellitus , biology , expression quantitative trait loci , methylation , quantitative trait locus , insulin resistance , biomarker , bioinformatics , medicine , gene , endocrinology , genotype , transcriptome , gene expression
This study provides a new perspective on the relationship between age‐related DNA methylation and insulin function. The hexokinase‐1 ( HK1 )’s methylation level in the whole blood can be considered as a potential biomarker for the risk of diabetes in healthy individuals.