A novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing

Clinical evidence indicates that the microenvironment in malignant pleural effusion (MPE) is immunologically cold, which impairs tumour immunosurveillance and antitumor immune response to immune checkpoint blockade (ICB). In a recent issue of Nature Nanotechnology , Liu et al. demonstrate a new nanotechnological approach to effectively mitigate the immune cold MPE and provide insights into its mechanism of action through single‐cell RNA‐sequencing.