Open AccessA novel nano‐immunotherapeutic remodels the immune landscape of malignant pleural effusion: Insights into its mechanism of action through single‐cell RNA‐sequencing
Author(s) -
Liu Yang,
Zhao Dawen
Publication year - 2022
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.774
Subject(s) - mechanism (biology) , immune system , rna , medicine , action (physics) , computational biology , pleural effusion , mechanism of action , cancer research , bioinformatics , biology , immunology , gene , genetics , physics , quantum mechanics , in vitro
Clinical evidence indicates that the microenvironment in malignant pleural effusion (MPE) is immunologically cold, which impairs tumour immunosurveillance and antitumor immune response to immune checkpoint blockade (ICB). In a recent issue of Nature Nanotechnology , Liu et al. demonstrate a new nanotechnological approach to effectively mitigate the immune cold MPE and provide insights into its mechanism of action through single‐cell RNA‐sequencing.