Open AccessPotential biomarkers and targets of mitochondrial dynamics
Author(s) -
Li Liyang,
Qi Ruixue,
Zhang Linlin,
Yu Yuexin,
Hou Jiayun,
Gu Yutong,
Song Dongli,
Wang Xiangdong
Publication year - 2021
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.529
Subject(s) - mitophagy , mitochondrion , mitochondrial dna , microbiology and biotechnology , mitochondrial fusion , biology , organelle , endoplasmic reticulum , endosome , computational biology , genetics , autophagy , apoptosis , intracellular , gene
Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria‐associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential diagnostic biomarkers and/or therapeutic targets for diseases, including mitophagy, mitochondrial dynamics, interactions between mitochondria and other organelles (lipid droplets, endoplasmic reticulum, endosomes, and lysosomes), as well as the regulation and posttranscriptional modifications of mitochondrial DNA/RNA (mtDNA/mtRNA). The direct and indirect influencing factors were especially illustrated in understanding the interactions among regulators of mitochondrial dynamics. In addition, mtDNA/mtRNAs and proteomic profiles of mitochondria in various lung diseases were also discussed as an example. Thus, alternations of mitochondria‐associated regulators can be a new category of biomarkers and targets for disease diagnosis and therapy.