Open AccessPyroptosis, metabolism, and tumor immune microenvironment
Author(s) -
Du Tiantian,
Gao Jie,
Li Peilong,
Wang Yunshan,
Qi Qiuchen,
Liu Xiaoyan,
Li Juan,
Wang Chuanxin,
Du Lutao
Publication year - 2021
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.492
Subject(s) - pyroptosis , context (archaeology) , immune system , tumor microenvironment , microbiology and biotechnology , programmed cell death , neuroscience , biology , immunology , computational biology , inflammasome , inflammation , apoptosis , genetics , paleontology
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic players in fate decisions of pyroptotic cells. Whether inflammatory characteristics induced by pyroptosis could cause damage the host or improve immune activity is largely dependent on the context, timing, and response degree. Here, we systematically review current points involved in regulatory mechanisms and the multidimensional roles of pyroptosis in several metabolic diseases and the tumor microenvironment. Targeting pyroptosis may reveal potential therapeutic avenues.