Open AccessThe human melanoma proteome atlas—Defining the molecular pathology
Author(s) -
Betancourt Lazaro Hiram,
Gil Jeovanis,
Kim Yonghyo,
Doma Viktória,
Çakır Uğur,
Sanchez Aniel,
Murillo Jimmy Rodriguez,
Kuras Magdalena,
Parada Indira Pla,
Sugihara Yutaka,
Appelqvist Roger,
Wieslander Elisabet,
Welinder Charlotte,
Velasquez Erika,
Almeida Natália Pinto,
Woldmar Nicole,
MarkoVarga Matilda,
Pawłowski Krzysztof,
Eriksson Jonatan,
Szeitz Beáta,
Baldetorp Bo,
Ingvar Christian,
Olsson Håkan,
Lundgren Lotta,
Lindberg Henrik,
Oskolas Henriett,
Lee Boram,
Berge Ethan,
Sjögren Marie,
Eriksson Carina,
Kim Dasol,
Kwon Ho Jeong,
Knudsen Beatrice,
Rezeli Melinda,
Hong Runyu,
Horvatovich Peter,
Miliotis Tasso,
Nishimura Toshihide,
Kato Harubumi,
Steinfelder Erik,
Oppermann Madalina,
Miller Ken,
Florindi Francesco,
Zhou Qimin,
Domont Gilberto B.,
Pizzatti Luciana,
Nogueira Fábio C. S.,
Horvath Peter,
Szadai Leticia,
Tímár József,
Kárpáti Sarolta,
Szász A. Marcell,
Malm Johan,
Fenyö David,
Ekedahl Henrik,
Németh István Balázs,
MarkoVarga György
Publication year - 2021
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.473
Subject(s) - proteome , melanoma , human proteome project , computational biology , pathology , histopathology , biology , proteomics , medicine , cancer research , bioinformatics , gene , genetics
The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in‐depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.