Open AccessTrophic effects of multiple administration of mesenchymal stem cells in children with osteogenesis imperfecta
Author(s) -
Ramesh Sowmya,
Daniel Dolly,
Götherström Cecilia,
Madhuri Vrisha
Publication year - 2021
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.385
Subject(s) - mesenchymal stem cell , regenerative medicine , medicine , stem cell , translational medicine , clinical trial , paracrine signalling , transcriptome , osteogenesis imperfecta , bioinformatics , translational research , pathology , biology , microbiology and biotechnology , genetics , gene expression , gene , receptor
The safety of mesenchymal stem cell therapy for osteogenesis imperfecta has been demonstrated previously. However, it is unknown how the trophic effects are mediated by stem cells. In the present commentary, we bring to the attention of readers the recent report by Infante et al in the journal of clinical and translational medicine. The TERCELOI clinical trial presented the possible paracrine effect of transplanted MSCs in vitro and i n vivo using proteomics and transcriptomic analysis. This novel finding adds new knowledge in the field of regenerative medicine. However, the scarcity of solid evidence in growth warrants a more thorough discussion.