Open AccessHindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling
Author(s) -
Sorrentino Carlo,
Ciummo Stefania Livia,
D'Antonio Luigi,
Lanuti Paola,
Abrams Scott I.,
Yin Zhinan,
Lu LiFan,
Di Carlo Emma
Publication year - 2021
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.278
Subject(s) - triple negative breast cancer , endogeny , cancer research , medicine , immunology , immunity , breast cancer , biology , cancer , immune system
IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells.