Open AccessNovel insights into the origin and development of CNS macrophage subsets
Author(s) -
Masuda Takahiro,
Amann Lukas,
Prinz Marco
Publication year - 2022
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1002/ctm2.1096
Subject(s) - choroid plexus , microglia , central nervous system , macrophage , neuroscience , meninges , immune system , parenchyma , biology , mechanism (biology) , medicine , pathology , immunology , inflammation , biochemistry , philosophy , epistemology , in vitro
The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS‐associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent studies have given novel insights into the nature of CAMs as compared to microglia. In this mini‐review, we summarise the current knowledge about the ontogenetic relationship and the underlying mechanism for the establishment of CNS macrophages during development.