Open AccessInterleukin‐22 in urinary tract disease – new experimental directions
Author(s) -
Ingersoll Molly A,
Starkey Malcolm R
Publication year - 2020
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1002/cti2.1143
Subject(s) - urinary system , urothelium , immune system , renal tubule , interleukin 22 , immunology , medicine , interleukin , biology , cytokine
Interleukin (IL)‐22 is expressed by immune cells in the urinary tract and IL‐22 receptor is expressed in urothelium and renal tubule cells. IL‐22 can be specifically targeted in the urinary tract or conditionally depleted in mice and targeted therapeutically in humans.