Open AccessImmunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women
Author(s) -
Lum FokMoon,
Narang Vipin,
Hue Susan,
Chen Jie,
McGovern Naomi,
Rajarethinam Ravisankar,
Tan Jeslin JL,
Amrun Siti Naqiah,
Chan YiHao,
Lee Cheryl YP,
Chua TzeKwang,
Yee WearnXin,
Yeo Nicholas KW,
Tan ThiamChye,
Liu Xuan,
Haldenby Sam,
Leo Yeesin,
Ginhoux Florent,
Chan Jerry KY,
Hiscox Julian,
Chong ChiaYin,
Ng Lisa FP
Publication year - 2019
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1002/cti2.1082
Subject(s) - zika virus , pregnancy , transcriptome , immune system , first trimester , medicine , virus , immunology , placenta , fetus , biology , andrology , virology , gene expression , gene , genetics
Objectives Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. Methods Full‐term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis. Results In this study, each woman exhibited a unique immune response with raised IL ‐1 RA , IP ‐10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS 3 antigens co‐localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF 2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies. Conclusion These findings should translate to improve clinical prenatal screening procedures for virus‐infected pregnant patients.