Open AccessOxidative and endoplasmic reticulum stress in respiratory disease
Author(s) -
Chen Alice CH,
Burr Lucy,
McGuckin Michael A
Publication year - 2018
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1002/cti2.1019
Subject(s) - endoplasmic reticulum , oxidative stress , inflammation , unfolded protein response , cystic fibrosis , medicine , disease , pathophysiology , lung , asthma , oxidative phosphorylation , pulmonary fibrosis , immunology , fibrosis , pathology , bioinformatics , biology , microbiology and biotechnology , biochemistry
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.