Open AccessRecent novel approaches to limit oxidative stress and inflammation in diabetic complications
Author(s) -
Pickering Raelene J,
Rosado Carlos J,
Sharma Arpeeta,
Buksh Shareefa,
Tate Mitchel,
Haan Judy B
Publication year - 2018
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1002/cti2.1016
Subject(s) - oxidative stress , inflammation , diabetes mellitus , medicine , disease , mechanism (biology) , intensive care medicine , burden of disease , disease burden , bioinformatics , immunology , biology , endocrinology , philosophy , epistemology
Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro‐ and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism‐based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.