Open AccessHuman FOXP 3 + T regulatory cell heterogeneity
Author(s) -
Mohr Audrey,
Malhotra Rajneesh,
Mayer Gaell,
Gorochov Guy,
Miyara Makoto
Publication year - 2018
Publication title -
clinical and translational immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.321
H-Index - 34
ISSN - 2050-0068
DOI - 10.1002/cti2.1005
Subject(s) - foxp3 , immune system , immunology , biology , immune tolerance , regulatory b cells , regulatory t cell , population , treg cell , homeostasis , cancer research , t cell , microbiology and biotechnology , medicine , il 2 receptor , interleukin 10 , environmental health
FOXP 3‐expressing CD 4 + T regulatory (Treg) cells are instrumental for the maintenance of self‐tolerance. They are also involved in the prevention of allergy, allograft rejection, foetal rejection during pregnancy and of exaggerated immune response towards commensal pathogens in mucosal tissues. They can also prevent immune responses against tumors and promote tumor progression. FOXP 3‐expressing Treg cells are not a homogenous population. The different subsets of Treg cells can have different functions or roles in the maintenance of immune homeostasis and can therefore be differentially targeted in the management of autoimmune diseases or in cancer. We discuss here how Treg cell subsets can be differentiated phenotypically, functionally and developmentally in humans.