Open AccessPreclinical platforms to study therapeutic efficacy of human γδT‐cells for oncology indications
Author(s) -
Barisa Marta,
Fowler Daniel,
Nattress Callum,
Fisher Jonathan
Publication year - 2022
Publication title -
clinical and translational discovery
Language(s) - English
Resource type - Journals
ISSN - 2768-0622
DOI - 10.1002/ctd2.72
Subject(s) - medicine , computational biology , cancer research , biology
In this commentary, we discuss recent advances in the study of γδT cell‐based immunotherapeutics. As an allo‐compatible cell therapy chassis without clear functional homologs in mice, γδT cells represent a challenge and an opportunity for preclinical modelling. We discuss some of the techniques and approaches that can be used to demonstrate and characterise γδT cell behaviour in biomimetic systems.