Open AccessClinical application of cell‐based therapies opportunities and challenges
Author(s) -
Gao Jie,
Wu Duojiao
Publication year - 2022
Publication title -
clinical and translational discovery
Language(s) - English
Resource type - Journals
ISSN - 2768-0622
DOI - 10.1002/ctd2.110
Subject(s) - clinical trial , immunosuppression , immunotherapy , medicine , immune system , cancer , cancer immunotherapy , oncology , cancer research , immunology
Immune checkpoint inhibitors or anti‐cancer immunotherapy using cellular transfer have emerged as new therapies in this field. These therapies work to overcome or alleviate tumour‐induced immunosuppression, resulting in immune‐mediated tumour clearance. Cellular therapies have the largest number of active agents and clinical trials. More targets have been explored, more trials have been opened and more patients have been recruited for trials as a result of recent advancements. In this article, we describe the latest developments and major obstacles in cell therapy for cancer treatment, starting with tumour‐infiltrating T cells.