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Reductive C−N Coupling of Nitroarenes: Heterogenization of MoO 3 Catalyst by Confinement in Silica
Author(s) -
Yang Fu,
Dong Xuexue,
Shen Yang,
Liu Mengting,
Zhou Hu,
Wang Xuyu,
Li Lulu,
Yuan Aihua,
Song Heng
Publication year - 2021
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202101203
Subject(s) - catalysis , nanoporous , mesoporous silica , heterogeneous catalysis , reusability , yield (engineering) , chemistry , aryl , alkyl , turnover number , mesoporous material , combinatorial chemistry , homogeneous , chemical engineering , materials science , organic chemistry , physics , software , computer science , engineering , metallurgy , thermodynamics , programming language
The construction of C−N bonds with nitroaromatics and boronic acids using highly efficient and recyclable catalysts remains a challenge. In this study, nanoporous MoO 3 confined in silica serves as an efficient heterogeneous catalyst for C−N cross‐coupling of nitroaromatics with aryl or alkyl boronic acids to deliver N ‐arylamines and with desirable multiple reusability. Experimental results suggest that silica not only heterogenizes the Mo species in the confined mesoporous microenvironment but also significantly reduces the reaction induction period and regulates the chemical efficiency of the targeted product. The well‐shaped MoO 3 @m−SiO 2 catalyst exhibits improved catalytic performance both in yield and turnover number, in contrast with homogeneous Mo catalysts, commercial Pd/C, or MoO 3 nanoparticles. This approach offers a new avenue for the heterogeneous catalytic synthesis of valuable bioactive molecules.