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Co‐Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions
Author(s) -
Elfinger Matthias,
Schönauer Timon,
Thomä Sabrina L. J.,
Stäglich Robert,
Drechsler Markus,
Zobel Mirijam,
Senker Jürgen,
Kempe Rhett
Publication year - 2021
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202100553
Subject(s) - catalysis , reductive amination , amination , microporous material , noble metal , chemistry , cobalt , hydrogen , primary (astronomy) , carbon fibers , inorganic chemistry , reducing agent , ammonia , combinatorial chemistry , organic chemistry , chemical engineering , materials science , physics , astronomy , engineering , composite number , composite material
Nanostructured and reusable 3d‐metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy‐to‐handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 °C and 10 bar H 2 pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed. The key for the high activity seemed to be the used support: an N‐doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores.