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Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions
Author(s) -
Aleku Godwin A.,
Roberts George W.,
Titchiner Gabriel R.,
Leys David
Publication year - 2021
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202100159
Subject(s) - carboxylation , carbon fixation , catalysis , chemistry , combinatorial chemistry , fixation (population genetics) , biochemical engineering , organic chemistry , biochemistry , carbon dioxide , engineering , gene
In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO 2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO 2 ‐fixation cascades.