Premium
Transition‐Metal‐Free Valorization of Biomass‐derived Levulinic Acid Derivatives: Synthesis of Curcumene and Xanthorrhizol
Author(s) -
Xu WenYan,
Zhuo KaiFeng,
Gong TianJun,
Fu Yao
Publication year - 2021
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202002167
Subject(s) - levulinic acid , chemistry , acylation , biomass (ecology) , organic chemistry , molecule , transition metal , catalysis , oceanography , geology
Levulinic acid (LA) is acknowledged one of the most promising biomass‐derived platform molecules and can be transformed into various value‐added chemicals. Here, we report a new reaction process for the valorization of LA derivatives under transition‐metal‐free condition. The protocol combined with the conversion of the levulinate to tosylhydrazone and base promoted arylation, acylation, and etherification cross‐coupling. Moreover, our method was applied to synthesize three biologically active molecules, rac ‐curcumene, rac ‐xanthorrhizol and rac ‐4,7‐dimethyl‐l‐tetralone. This reaction discloses a new avenue for the high‐value utilization of platform molecules.