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Cross‐Dehydrogenative Alkynylation: A Powerful Tool for the Synthesis of Internal Alkynes
Author(s) -
Zhang JiShu,
Liu Long,
Chen Tieqiao,
Han LiBiao
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202001165
Subject(s) - alkynylation , organic synthesis , combinatorial chemistry , chemistry , molecule , nanotechnology , chemical synthesis , organic molecules , green chemistry , computer science , organic chemistry , catalysis , materials science , supramolecular chemistry , biochemistry , in vitro
Alkynes are among the most fundamentally important organic compounds and are widely used in synthetic chemistry, biochemistry, and materials science. Thus, the development of an efficient and sustainable method for the preparation of alkynes has been a central concern in organic synthesis. Cross‐dehydrogenative coupling utilizing E−H and Z−H bonds in two different molecules can avoid the need for prefunctionalization of starting materials and has become one of the most straightforward methods for the construction of E−Z chemical bonds. This Review summarizes recent progress in the preparation of internal alkynes by cross‐dehydrogenative coupling with terminal alkynes.