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Green Asymmetric Organocatalysis
Author(s) -
Krištofíková Dominika,
Modrocká Viktória,
Mečiarová Mária,
Šebesta Radovan
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202000137
Subject(s) - organocatalysis , green chemistry , ionic liquid , chemistry , enantioselective synthesis , solvent , organic chemistry , eutectic system , catalysis , combinatorial chemistry , nanotechnology , materials science , alloy
Asymmetric organocatalysis is becoming one of the main tools for the synthesis of chiral compounds that are needed as medicines, crop protection agents, and other bioactive molecules. It can be effectively combined with various green chemistry methodologies. Intensification techniques, such as ball milling, flow, high pressure, or light, bring not only higher yields, faster reactions, and easier product isolation, but also new reactivities. More sustainable reaction media, such as ionic liquids, deep eutectic solvents, green solvent alternatives, and water, also considerably enhance the sustainability profile of many organocatalytic reactions.