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Synthesis of NH‐Sulfoximines by Using Recyclable Hypervalent Iodine(III) Reagents under Aqueous Micellar Conditions
Author(s) -
Zhang Guocai,
Tan Hongsheng,
Chen Weichun,
Shen Hong C.,
Lu Yue,
Zheng Changwu,
Xu Hongxi
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.201903430
Subject(s) - hypervalent molecule , reagent , iodine , aqueous solution , chemistry , catalysis , extraction (chemistry) , pulmonary surfactant , combinatorial chemistry , iodine compounds , organic chemistry , biochemistry
The synthesis of NH‐sulfoximines from sulfides has been first developed under mild conditions in an aqueous solution with surfactant TPGS‐750‐M as the catalyst at room temperature. In this newly developed process, a simple and convenient recycling strategy to regenerate the indispensable hypervalent iodine(III) is used. The resulting 1,2,3‐trifluoro‐5‐iodobezene can be recovered almost quantitively from the mixture by liquid–liquid extraction and then oxidized to give the corresponding iodine(III) species. This optimized procedure is compatible with a broad range of functional groups and can be easily performed on a gram scale, providing a green protocol for the synthesis of sulfoximines.